ChemCatChem
Petra Kuzman, Franc Požgan, Anton Meden, Jurij Svete, Bogdan Štefane
The synthesis of a range of new cyclometallated organoruthenium(II) complexes through the ortho‐C−H activation of the aryl group in 2‐aryl‐substituted quinazolines with [RuX2(p‐cymene)]2 is described. The beneficial effect of the carboxylate ligand on both the cyclometallation and the further arylation reaction step was demonstrated. Mechanistic studies reveal that bromide and iodide anions decelerate the arylation process by an in situ ligand exchange reaction. Additionally, a detailed NMR spectroscopy investigation was performed to explain some elementary steps in the arylation of 2‐(aryl)quinazoline halidoruthenacycles.
Read article: ChemCatChem, 2017, 9, 3380-3387
