Advanced Synthesis & Catalysis
Sebastijan Ričko, Jurij Svete, Bogdan Štefane, Andrej Perdih, Amalija Golobič, Anže Meden, Uroš Grošelj
Chiral 1,2‐diamines are privileged structural motifs in organocatalysis, whereas efficient 1,3‐diamine‐derived organocatalysts are very rare. Herein we report a highly efficient camphor‐1,3‐diamine‐derived squaramide organocatalyst. Its catalytic activity in Michael additions of 1,3‐dicarbonyl nucleophiles to trans‐β‐nitrostyrene derivatives provides excellent enantioselectivities (up to >99% ee).
Read article: Adv. Synth. Catal., 2016, 358, 3786-3796
