03.10.2022
In Advanced Synthesis & Catalysis an organocatalyzed Michael addition of N-substituted tetramic acids to nitroalkene acceptors followed by O-alkylation to give polyfunctionalized tetramic acids has been presented. Moreover, quantum chemical methods provided the mechanistic insights of the studied transformation. Additionally, a comparative study of the alkylation of a selected tetramic and tetronic acid with trans-β-nitrostyrene is disclosed.
In Catalysts a total of 24 novel organocatalysts based on (S)-quininamine as a chiral tertiary amine and on enaminone or 1,2-benzenediamine as hydrogen bond donors were synthesized. Their organocatalytic activity was evaluated in the Michael addition of acetylacetone to trans-β-nitrostyrene and the enantioselectivities of up to 72% ee were observed.
16.08.2022
A new article has been published in Molecules describing in silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1H-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase of Plasmodium falciparum (PfDHODH).
21.03.2022
A novel article has been published in Dyes and Pigments descibing a series of 2-acyl-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole derivatives synthesized by using a copper-catalyzed azomethine-imine-alkyne cycloaddition as versatile fluorescent probes with a remarkably large Stokes shift.
26.01.2022
PhD student Luka Ciber published an article in Advanced Synthesis & Catalysis on the mechanistic insight into annulation of arylidene-Δ2-pyrrolin-4-ones by cinchona squaramide-based organocatalysts.
Congratulations Luka!
14.10.2021
Congratualtions dr. Nejc Petek on successfully defending your PhD thesis.
13.06.2021
Nejc Petek has published an interesting paper in Organic Letters disclosing Visible-light induced chemoselective C-N bond cleavage in anti-bimane-like derivatives. The publication has been highlighted by the journal as a cover.
Congratulations to Nejc!
