Microwave‐Assisted Direct Amidation of Ethyl 1‐Phenyl‐5‐hydroxy‐1H‐pyrazole‐4‐carboxylate


Journal of Heterocyclic Chemistry

Mladena Milošević, Ines Šterbal, Urban Feguš, Jernej Baškovč, Benjamin Prek, Uroš Grošelj, Branko Stanovnik, Jurij Svete

Microwave‐assisted treatment of ethyl 5‐hydroxy‐1‐phenyl‐1H‐pyrazole‐4‐carboxylate with excess primary aliphatic amines in 1‐propanol at 140°C and with excess pyrrolidine or piperidine in 2‐methoxyethanol at 180°C produced the corresponding carboxamides in good yields.

Read article: J. Heterocyclic Chem., 2015, 52, 556-561